Keywords

DNA Repair; Microscopy; Nuclear Envelope

Research interests

My main research focus is still nuclear biology. After years of research in this field, I moved on to head the centralized light microscopy facility at Max Perutz labs.Here I service researchers to meet their experimental demand in the field of Biooptics. We think we are a big puzzle-piece at the technological side of successful biomedical research for many of the scientists.

Techniques, methods & infrastructure

Confocal microscopy; Live Imaging; High Content Imaging Screening; Superresolution Microscopy; TIRF Microscopy;

Selected publications

1. Garbrecht, J. et al., 2018. Simultaneous dual-channel imaging to quantify interdependent protein recruitment to laser-induced DNA damage sites. Nucleus, 9(1), pp.474,
2. Kaufmann, T. et al., 2017. A novel non-canonical PIP-box mediates PARG interaction with PCNA. Nucleic Acids Research, 45(16), pp.9741,
3. Brachner, A. et al., 2012. The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo. Journal of Cell Science, 125(4), pp.1048,
4. Brachner, A., 2005. LEM2 is a novel MAN1-related inner nuclear membrane protein associated with A-type lamins. Journal of Cell Science, 118(24), pp.5797,
5. Padmakumar, V.C., 2005. The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope. Journal of Cell Science, 118(15), pp.3419,